[关键词]
[摘要]
中医药发展有数千年的历史,临床应用有独特的优势。临床普遍认为中药毒副作用少、服用安全,但是随着近几年中药肝毒性、肾毒性、心脏毒性等临床病例及基础研究报道逐渐增多,中药毒性备受关注。心脏毒性评价是药物临床试验前必须考量的重要指标,对中药新药研发、中医药的临床安全规范应用也有着至关重要的作用。如何识别中药心脏毒性,掌握其临床特点、检测指标、评价方法、诊断要素是目前面临的主要问题。就近年来中药心脏毒性的研究及临床前评价技术进行总结,并对中药心脏毒性的临床评价方法进行探讨与思考。
[Key word]
[Abstract]
Traditional Chinese medicine has developed for thousands of years, and its clinical application has unique advantages. It is generally believed that Chinese medicine (CM) has few toxic and side effects and it is safe. However, in recent years, more and more clinical cases and basic research reports about hepatotoxicity, nephrotoxicity, and cardiotoxicity of CM have been reported. Therefore, we also increasingly concerned about the toxicity of Chinese materia medica (CMM). Cardiotoxicity assessment is an important index that must be considered before clinical trials of drugs. It also plays an important role in the research and development of new Chinese medicines and the standardized application of clinical safety of CM. Then, how to identify the cardiotoxicity of CMM, grasp the clinical characteristics, detection indicators, evaluation methods, and diagnostic elements are the main problems we are facing. In this paper, we summarized many researches and pre-clinical evaluation techniques of cardiotoxicity of CMM in recent years, and discussed and considered the clinical evaluation methods of cardiotoxicity of CMM.
[中图分类号]
[基金项目]
河南省高校科技创新团队支持计划(13IRTSTHN012);河南省科技厅中医药防治心血管疾病创新型科技团队(C20130050);国家自然科学基金面上项目(81774049)