[关键词]
[摘要]
寡肽作为生物医药的重要组成部分,其组成简单、安全指数高,但受限于寡肽药物设计理论和发现途径远远小于其他结构类型药物,使得新型生物活性寡肽的获得成为该领域研究的热点和难点。中药作为天然的寡肽库,含有大量的活性寡肽。其中中药寡肽具有神经保护、保肝、抗肿瘤、抗凝血、抗氧化、增强免疫力等生物活性。重点对近10年来国内外学者从中药中发现的活性寡肽的序列、生物活性进行综述,并探索活性寡肽与中药分类之间的关联,初步提示补虚、活血化瘀等类中药作为天然寡肽源头成果多、易成功,为活性寡肽新药的开发提供方向和思路。
[Key word]
[Abstract]
Oligopeptides are simple in composition, high in safety index and good in drug preparation, which are important components of biomedicine. However, due to the limitation of oligopeptide drug design theory and discovery pathways which are far less than other structural drugs, obtaining new bioactive oligopeptides is a hot and difficult topic in this field. As a natural oligopeptide library, Chinese materia medica (CMM) contains a large number of active oligopeptides. Oligopeptides of CMM have vital biological activities such as neuroprotection activity, liver protection activity, antitumor, anticoagulation, anti-oxidation, immunity enhancement, etc. In this paper, the sequence and biological activity of active oligopeptides discovered by scholars at home and abroad in the past 10 years were reviewed, and the relationship between active oligopeptides and classification of CMM was explored. It is preliminarily suggested that CMM such as tonifying deficiency drugs and promoting blood circulation and removing blood stasis are the sources of natural oligopeptides. There are many research results easy to be successful in the research and development of new oligopeptide drugs, which provides directions and ideas for the development of new active oligopeptide drugs.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(81603256);中华中医药学会青年人才托举工程项目(CACM-2018-QNRC2-B08);中央高校基金科研业务项目(BUCM-2019-JCRC002);中央高校基金科研业务项目BUCM-2018-2020);中央高校基金科研业务项目(2019-JYB-TD005);北京中药基础与新药研究重点实验室(100102)