[关键词]
[摘要]
目的 研究小花清风藤Sabia parviflora的化学成分。方法 利用硅胶柱色谱、HP20树脂、以及半制备型液相色谱等,多种色谱技术进行分离,运用现代光谱技术鉴定化合物结构。结果 从小花清风藤中分离得到15个化合物,分别鉴定为1,3,5-三甲氧基苯(1)、香草醛4-O-β-D-葡萄糖苷(2)、2,6-二甲氧基-4-羟基苄醇1-O-β-D-葡萄糖苷(3)、rel-5-(3S,8S-dihydroxy-1R,5S-dimethyl-7-oxa-6-oxobicyclo[3,2,1]-oct-8-yl)-3-methyl-2Z,4E-penta-dienoic acid(4)、原儿茶酸(5)、4-喹啉酮-2-羧酸(6)、3,4,5-三甲氧基苯甲酸(7)、邻苯二酚(8)、丁香酸-4-O-β-D-吡喃葡萄糖苷(9)、(-)-(7α,8S)-erythro-1-C-syringylglycerol 4-O-β-D-glucopyranoside(10)、3,4,5-三甲氧基苯甲酸(11)、1,2,4-苯三酚(12)、阿魏酸(13)、香草酸(14)、对羟基苯甲酸(15)。结论 化合物1~11均为首次从该属植物中分离得到,12~15为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from Sabia parviflora. Methods Various column chromatographic techniques were used to separate and purify the chemical constituents which structures were elucidated by spectral analysis. Results Fifteen compounds were isolated and identified as 1,3,5-trimethoxybenzene (1), vanillic aldehyde 4-O-β-D-glucopyranoside (2), 2,6-dimethoxy-4-hydroxybenzyl alcohol 1-O-β-D-glucopyranoside (3), rel-5-(3S,8S-dihydroxy-1R,5S-dimethyl-7-oxa-6-oxobicyclo[3,2,1]-oct-8-yl)-3-methyl-2Z,4E-penta-dienoic acid (4), protocatechuic acid (5), 4-quinolinone-2-caboxylic acid (6), 3,4,5-trimethoxy benzoic acid (7), pyrocatechol (8), syringic acid-4-O-β-D-glucopyranoside (9), (-)-(7α,8S)-erythro-1-C-syringylglycerol 4-O-β-D-glucopyranoside (10), 3,4,5-trimethoxy benzoic acid (11), 1,2,4-trihydroxybenzene (12), ferulic acid (13), vanillic acid (14), and p-hydroxybenzoic acid (15). Conclusion Compounds 1-11 are isolated from the genus of Sabia for the first time, and compounds 12-15 are isolated from this plant for the first time.
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[基金项目]
江西省杰出青年资助计划项目(20162BCB23003);江西省百千万人才工程资助[赣人社字(2016)332号];江西中医药大学学科建设项目(JXSYLXK-ZHYAO017);南昌市中药与天然药物活性成分研究知识创新团队(洪科字[2018]274号)