中医药动物模型广泛应用于中医药研究领域，病证结合模型成为当前中医药动物模型发展的趋势。通过查阅文献发现中医药动物模型制备尚存在：所选动物与疾病人群体质不符，部分疾病缺乏证候体现，疾病与证候关联性不强，缺乏病证结合动物模型评价体系等问题。模型应用存在：忽视模型的周期性；忽视环境对动物模型的影响的问题；单以正常动物进行中医药毒理研究不符中医药本质。从6方面提出：与发病人群相符体质的动物造模；扩大病证结合动物模型使用范围；运用中医药理论"五运六气""子午流注""七情""六淫"气候箱，并以"四诊信息"合参解决病证关联性不强问题；采用"证候"指标+"病"指标，从四诊信息、生化指标、分子生物学等方面完善模型评价标准；在模型应用中重视模型周期性，尤其重视环境对动物模型"证候"形成的影响；毒理研究中考虑增设模型动物组，以调整中药应用剂量，提升中药药效。通过以上问题的改善，以期为中医药动物模型的完善及正确应用提供相关参考。

Traditional Chinese medicine animal models are widely used in the field of traditional Chinese medicine research. The combination of disease and syndrome models has become the trend of the development of traditional Chinese medicine animal models. In this paper, we find that model manufacturing still exists problems as following through literature review:the selected animals are not in conformity with the constitution of disease population; some diseases lack syndrome manifestation; the correlation between diseases and syndromes are not strong; the disease syndrome combined with animal model evaluation system is deficient and etc. The application of the model exists:ignore the periodicity of the model; ignore the impact of the environment on the animal model; toxicological research has the problem that normal animals are not suitable for TCM toxicology research. This paper proposes from six aspects:construct the animal model that conforms to the constitution of diseased population; expand the scope of use of the disease and syndrome combined animal model; use the theory of traditional Chinese medicine of "five transports and six qi", "streamer midnight-midday ebb flow", "seven emotions", and "six kinky" climate box, and combined with "four diagnosis information" to solve the problem of weak correlation between diseases and syndromes; using "syndrome" index + "disease" indicators to improve the model evaluation criterion from four diagnostic information, biochemical indicators, molecular biology, and etc. Pay attention to the periodicity of the model, and pay particular attention to the influence of the environment on the formation of the animal model syndrome; In the toxicology research, the model animal should be used instead of the normal animal application, and the dosage of the traditional Chinese medicine should be adjusted to improve the efficacy of traditional Chinese medicine. Through the improvement of the above problems, it is expected to provide relevant reference for the improvement of the animal model of Chinese medicine and its correct application.

国家行业科研专项（201507004-2）；国家国际合作基地（2016-65）