免疫逃逸是肿瘤发生发展的重要机制，重新激活人体的抗肿瘤免疫反应是治疗恶性肿瘤的重要举措。人参皂苷Rg₃（ginsenoside Rg₃，G-Rg₃）是从人参中分离提取的一种固醇类化合物，可以通过上调肿瘤细胞自身抗原性与免疫原性、增强免疫效应细胞及免疫活性分子功能、调节局部免疫微环境等机制提高机体的抗肿瘤免疫能力。但是，水溶性差、生物利用度低等原因限制了G-Rg₃的临床应用。纳米给药体系是解决这一问题的关键。综述G-Rg₃对肿瘤的免疫调节作用及其纳米给药体系的研究进展，以期为G-Rg₃的深入研究和临床应用提供参考。

Immune escape is an important mechanism for the development of tumors. Re-activating the anti-tumor immune response is a key measure for the treatment of malignant tumors. Ginsenoside Rg₃ (G-Rg₃) is a sterol compound isolated from Panax ginseng. It can improve the anti-tumor immune response of human by up-regulating the autoantigenicity and immunogenicity of tumor cells, enhancing the function of immune effector cells and immune active molecules, and regulating the local immune microenvironment. However, the clinical application of G-Rg₃ is limited due to its poor water solubility and low bioavailability. Improved drug delivery systems are the key to solving this problem. Therefore, this paper summarizes the research progress of G-Rg₃ on tumor immunoregulation and its nano-drug delivery systems, in order to provide reference for the in-depth study and clinical application of G-Rg₃.

国家自然科学基金资助项目（81430101）