根据国内外的文献进行总结、归纳、分析，较为全面地阐述近些年黄酮类、多糖类、生物碱类等中药有效成分对肿瘤细胞G₂/M期调控的方式、途径等研究进展。多数中药有效成分是通过影响Cyclin-CDK复合物或通过诱发DNA损伤、有丝分裂缺陷和胞质分裂失败而引起肿瘤细胞发生有丝分裂灾难进而使肿瘤细胞阻滞于G₂/M期，从而抑制肿瘤细胞增殖，最终诱导凋亡。中药有效成分可以通过上调或抑制G₂/M检测点的关键基因，将肿瘤细胞阻滞在G₂/M期，抑制细胞生长，诱导细胞凋亡，从而发挥抗肿瘤作用。

According to the literatures at home and abroad, this paper comprehensively summarized and analyzed the research progress of regulation ways and means of various active ingredients of Chinese materia medica (CMM) on G₂/M phase of tumor cells in recent years. Most of the active ingredients of CMM cause mitotic disaster of tumor cells by affecting Cyclin-CDK complex or inducing mitotic catastrophe in tumor cells, inducing DNA damage, mitotic defects and cytokinesis failure, thereby blocking tumor cells in G₂/M phase, thus inhibiting tumor cell proliferation and finally inducing apoptosis. The active constituents of CMM can inhibit tumor growth and induce apoptosis by up-regulating or inhibiting key genes at the G₂/M detection site, arresting tumor cells in G₂/M phase, thereby exerting antitumor effects.

中国博士后科学基金（2015M581467）；黑龙江省博士后特别资助（LBH-TZ1613）；黑龙江省博士后科学基金（LBH-Z15107）；哈尔滨市青年科技创新人才专项基金（2013RFQXJ150）；黑龙江省青年创新人才培养计划（UNPYSCT-2015017）；哈尔滨商业大学校级科研项目（17XN061）；哈尔滨商业大学研究生创新科研基金项目（YJSCX2018-544HSD）