哮喘是由多种因素引起，多种细胞及细胞组分参与的慢性气道炎症，常伴随引起气道高反应性、气道重塑。目前，哮喘已经成为一种常见的慢性呼吸系统疾病。哮喘的发生发展及药物治疗与机体信号通路调节具有密切的联系。目前研究较多的哮喘通路有MAPK通路、PI3K/Akt通路、NF-κB通路、TGF-β通路、Notch通路以及Wnt通路等。中药较化学药在治疗哮喘等慢性疾病方面具有一定的优势，为了进一步阐明中药对哮喘发病机制的干预优势及开发治疗哮喘的中药，对中药干预哮喘信号通路的作用研究进展进行综述。同时，结合文献对哮喘通路及发病机制（气道炎症、高反应性、气道重塑）的关系进行了总结。

Asthma is a chronic airway inflammation caused by a variety of factors, involving a variety of cells and cellular components, which is often accompanied by airway hyperresponsiveness and airway remodeling. At present, asthma has become a common chronic respiratory disease. There exists close relationship between the asthma and signaling pathways. MAPK, PI3K/Akt, NF-κB, TGF-β, Notch and Wnt pathways related to the asthma were extensively studied currently. Traditional Chinese medicine shows advantages in the treatment of chronic diseases such as asthma. In order to explain the advantages of traditional Chinese medicine in the treatment of asthma and develop new asthma drugs originated from traditional Chinese medicine, the role of traditional Chinese medicine in the intervention of related signaling pathways of asthma was reviewed. In addition, the relationship between signaling pathway and pathogenesis (airway inflammation, airway hyperresponsive, and airway remodeling) were also discussed.

国家自然科学基金资助项目（31270008）；国家中药标准化项目（ZYBZH-Y-JIN-34）；山西省科技创新重点团队（201605D131045-18）；地产中药功效物质研究与利用山西省重点实验室（201605D111004）