[关键词]
[摘要]
目的 优选青香乳康颗粒中挥发油的提取及包合工艺。方法 运用Box-Behnken优化青香乳康颗粒中挥发油的提取工艺,基于PCA-G1-熵权法和L9(34)正交设计,采用胶体磨法,以芳香水中油水比、油β-环糊精比和研磨时间为考察因素,以包合率以及包合物的收得率为评价指标,优选挥发油的最佳包合工艺。结果 挥发油的最佳提取工艺为浸泡0 h,加水量为10倍,提取6 h。挥发油的最佳包合工艺为芳香水中油水比1∶80,每毫升挥发油中加入6 g β-环糊精,研磨30 min。在此条件下,分别进行3批验证试验,试验数据组间无明显差异。结论 优选的挥发油提取及包合工艺稳定可行,为大生产提供实验依据。
[Key word]
[Abstract]
Objective To optimize the extraction technology and inclusion process of volatile oil for Qingxiangrukang Granules (QG). Methods Box-Behnken was used to optimize the extraction technology of volatile oil in QG. With yield of inclusion compound and inclusion rate of volatile oil-β-CD as evaluation indexes, and with volatile oil-pure water ratio, β-CD-volatile oil ratio, and inclusion time as investigate factors, the optimal inclusion technology for volatile oil of QG was ensured based on PCA-G1-entropy method and orthogonal design and by using colloid milling. Results The optimum extraction technology of volatile oil were as follows:extracting time was 6 h, liquid-material ratio was 10, immersion was 0 h. The optimal inclusion technology for volatile oil were as follows:pure water-volatile oil ratio was 1:80, β-CD-volatile oil ratio was 6 g, and the inclusion time was 30 min. Under such condition, there was no significant difference between verification groups of three batches. Conclusion This optimal extraction technology and inclusion process is stable and workable and can provide experimental basis for industrial production of QG.
[中图分类号]
[基金项目]
中央引导地方科技发展专项项目(2018TZYD0003)