[关键词]
[摘要]
代谢组学作为系统生物学的重要组成部分,是与表型更接近的组学,具有整体性、客观性、灵敏性和动态性的特点,使其在中医药研究领域得到迅速的应用和推广。归纳总结代谢组学在逍遥散抗抑郁药理机制、药效标志物筛选、抗抑郁新药研发等方面的应用进展。研究结果发现逍遥散可以通过能量代谢和肠道菌群代谢途径的纠偏作用达到治疗效果;氨基酸、糖类等物质可能是抑郁症的诊断标志物或逍遥散抗抑郁的疗效标志物;在充分挖掘逍遥散抗抑郁作用科学内涵的基础上,创制抗抑郁中药新药,为经典方剂的传承与发展提供新思路,探索新途径。
[Key word]
[Abstract]
Metabolomics, as an important part of systematic biology, is more closely related to phenotype, and has the characteristics of integrity, objectivity, sensitivity and dynamics, which enables it to be rapidly applied and popularized in the research field of traditional Chinese medicine. In this paper, the application of metabolomics in antidepressant pharmacological research, screening of pharmacodynamic markers and development of new antidepressant drugs were summarized. Xiaoyao Powder can achieve the therapeutic effect through the rectifying effect of energy metabolism and intestinal microflora metabolism. Amino acids, sugars, and other substances may be the diagnostic markers of depression or therapeutic markers of Xiaoyao Powder. On the basis of fully exploring the scientific connotation of the antidepressant effect of Xiaoyao Powder, a new antidepressant medicine was created to provide new ideas and explore new approaches for the inheritance and development of the classic formula.
[中图分类号]
R285
[基金项目]
国家"重大新药创制"科技重大专项(2017ZX09301047);中国博士后科学基金面上资助项目(2016M602414);山西省科技重点研发计划项目(201603D3113013);山西省科技重点研发计划项目(201603D321077);山西省自然科学基金项目(201701D22111344);山西省重点实验室资助项目(201605D111004);山西省科技创新重点团队资助项目(201605D131045-18);山西省研究生教育创新项目(2016SY007);山西省研究生教育创新项目(2017JD02)