[关键词]
[摘要]
目的 探讨癃清片辅助治疗急性附睾炎的安全性及临床疗效。方法 将80例18~40岁的急性附睾炎患者随机分为对照组和试验组。对照组给予抗菌药物治疗,试验组采用抗菌药物联合癃清片(6片/次,每天3次)治疗,治疗14 d。观察两组临床疗效,记录疼痛缓解时间,治疗前后对患者精液进行分析。结果 试验组患者治疗14 d后单纯显效28例,单纯有效12例,无效0例,显效率70.0%,总有效率100%;对照组患者治疗14 d后单纯显效19例,单纯有效18例,无效3例,显效率47.5%,总有效率92.5%;试验组显效率及总有效率高于对照组,差异显著(P<0.05)。治疗前两组患者精子总活力、正常形态精子率、精子浓度比较差异无统计学意义(P>0.05),治疗14 d后两组患者精子总活力、正常形态精子率、精子浓度均高于治疗前水平(P<0.05),且试验组精子总活力、正常形态精子率、精子浓度优于对照组,差异显著(P<0.05)。试验组疼痛缓解时间(51.0±28.5)h短于对照组的(70.0±23.5)h,差异显著(P<0.05)。治疗后2个月复查阴囊彩超,试验组阴囊彩超提示附睾结节形成5例,对照组阴囊彩超提示附睾结节形成9例。结论 癃清片辅助治疗急性附睾炎安全有效,可有效缓解患者疼痛、促进炎症减退等,且对精液质量无明显不良影响,值得应用和推广。
[Key word]
[Abstract]
Objective To explore the safety and clinical efficacy of Longqing Tablets in the adjuvant treatment of acute epididymitis. Methods A total of 80 cases of acute epididymitis aged from 18 to 40 were randomly divided into control group and observation group. The control group was treated with antibiotics, while the observation group was treated with antibiotics combined with Longqing Tablets (six tablets per time, bid) for 14 d. The clinical efficacy, obvious and effective rate, pain relief time, semen analysis before and after treatment were compared between the two groups. Results After two weeks of treatment, 28 patients in the observation group were effective, 12 patients were effective, 0 patients were ineffective, the marked efficiency was 70.0%, the total effective rate was 100%. Totally 19 patients in the control group were effective, 18 patients were effective, three patients were ineffective, the marked efficiency was 47.5%, and the total effective rate was 92.5%. The marked efficiency and total effective rate in the observation group were higher than those in the control group, the difference was statistically significant (P < 0.05). There was no significant difference in total sperm motility, normal morphological sperm rate and sperm concentration between the two groups before treatment (P > 0.05). Two weeks after treatment, the total sperm motility, normal morphological sperm rate and sperm concentration in the observation group were better than those in the control group, and the difference was statistically significant (P < 0.05). The pain relief time of the observation group (51.0 ±28.5) h was shorter than that of the control group (70.0 ±23.5) h, and the difference was statistically significant (P < 0.05). Two months after treatment, the scrotal color Doppler ultrasonography showed five cases of epididymal nodules in the observation group and nine cases in the control group. Conclusion Longqing Tablets are safe and effective in the adjuvant treatment of acute epididymitis. It can effectively relieve pain and promote the decline of inflammation, and has no obvious adverse effect on semen quality. The effect of continuous application is exact, which is helpful to shorten the course of disease, and is worthy of application and promotion.
[中图分类号]
R287.3
[基金项目]