目的 制备石英砂修饰-蛇床子素表面分子印迹材料，用扫描电镜和红外光谱表征，并对分子印迹材料进行吸附性能考察。方法 采用N-氨乙基-3-氨丙基甲基二甲氧基硅烷（KH-602）修饰的石英砂作为载体，蛇床子素（OST）为模板分子，甲基丙烯酸（MAA）为单体，乙二醇二甲基丙烯酸酯（EGDMA）为交胶剂，偶氮二异丁腈（AIBN）为引发剂，甲醇为溶剂制备蛇床子素表面分子印迹材料（MIP），采用扫描电镜观察了分子印迹材料表面，用红外光谱对分子印迹材料的化学结构进行表征。结果 动态吸附表明分子印迹材料对蛇床子素随时间增加吸附量逐渐达到饱和，静态吸附研究分子印迹材料对蛇床子素的最大吸附量（16.71 mg/g），选择性吸附结果表明，分子印迹材料对蛇床子素具有特异的结合性能与分子识别特性。结论 分子印迹材料对蛇床子素具有特异的识别选择性、优良的结合亲和性及洗脱性，蛇床子素分子印迹材料对蛇床子素的吸附能力明显强于花椒毒素和欧前胡素。

Objective The molecularly imprinted osthole on surface-modified quartz sand was prepared and characterized by SEM and FT-IR. The adsorption properties of molecularly imprinted materials were investigated. Methods The morphology of MIP was prepared using N-(β-aminoethyl)-γ-aminopropylmethylbimethoxy silane (KH-602) modified quartz sand as supporter, osthole as template, methacrylic acid (MAA) as functional monomer, ethylene glycol dimethacrylate (EGDMA) as crosslinker, axodiisobutyronitrile (AIBN) as initiator, and methanol as porogen, observed by SEM, and the chemical structure of MIP was characterized by FT-IR. Results The dynamic adsorption experiment showed that the adsorption capacity of molecularly imprinted materials to osthole gradually reached saturation with the increase of time. The maximum adsorption capacity of molecularly imprinted materials for osthole was studied by static adsorption experiment. The selective adsorption experiment was adopted to study the binding properties and molecule recognition characters of molecularly imprinted materials for osthole. Conclusion The experimental results showed that MIP had specific recognition selectivity, excellent binding affinity and elution property for ractopamine. The MIP on the adsorption ability of osthole was significantly better than xanthotoxin and imperatorin.

R283.6

贵州省科技厅科学技术基金项目（黔科合LH字[20157629]号）；六盘水市科技局科技创新平台：六盘水高性能纤维与先进多孔材料重点实验室（52020-2017-02-02）；六盘水师范学院校级③基金项目；六盘水师范学院重点学科-化学（LPSSYZDXK201602）