在前期提出超分子化学对中药四性理论特殊影响的基础上，进一步分析中药升降浮沉的历史沿革、研究概况，并运用超分子"印迹模板"理论对中药"升降浮沉"理论进行解析，提出对中药"升降浮沉"的评价方法。人体与中药均是印迹模板印迹作用的聚集体，在印迹模板作用规律下，不同类型的中药成分与人体的靶点通过"锁-钥"关系以非共价键结合，中药客体超分子通过键的作用可纠正人体主体超分子在自识别、自组织、自组装、自复制过程时发生的寒热、气机失调。人体具备抵抗外界病邪侵袭的能力，有赖于其气机"升降出入"的正常；中药具有"升降浮沉"的性能并能祛除病疾，有赖于其能调整人体气机紊乱，或顺应气机、祛邪外出以增强机体免疫的能力。基于此，在分析中药"升降浮沉"药理作用的基础上，探究其物质基础，并建立中药"升降浮沉"的评价方法，通过超分子印迹模板理论对中药升降浮沉进行剖析，揭示其科学内涵，推动中药药性理论不断创新。

Based on the special influence of supramolecular chemistry on the four-character theory of Chinese materia medica (CMM) proposed in the early stage of this laboratory, this paper further analyzes the historical evolution and research situation of CMM lifting and lowering, and uses the supramolecular "imprint template" theory to analyze the "lifting and sinking" of CMM, and proposes evaluation method of CMM floating and sinking. The human body and CMM are "imprinted templates" of the aggregation of imprinting function, under the effect of the "imprinting template", different types of Chinese native medicine ingredient targets with human targets through "lock-and-key" relationship in non covalent bond, the role of CMM object supramolecular by key can correct human body supramolecular in the processes of self-recognition, self-organization, self-assembly, self-replication when the fever, disorder of qi occurs. The human body has the ability to resist the invasion of external diseases and pathogens, which depends on the normal "rise and fall" of human qi; CMM has the property of floating and sinking, and can eliminate diseases. It depends on its adjustment of qi disorder of human body, or compliance with qi and removing pathogens to enhance the ability of immunity. Based on this, on the basis of analyzing the pharmacological effects of the rise and fall of CMM, the material basis of the lifting and lowering of CMM was explored, and the evaluation method of the lifting and lowering of traditional Chinese medicine was established. The supramolecular "imprinting template" theory is used to analyze the lifting and lowering of CMM, revealing its scientific connotation and promoting the continuous innovation of CMM pharmacology theory.

国家自然科学基金项目（81573691）；国家自然科学基金项目（81874507）；国家自然科学基金项目（81874344）；湖南省自然科学基金项目（2018JJ2297）；湖南省自然科学基金项目（2016JJ4065）；湖南省教育厅科学研究重点项目（16A162）；药学湖南省重点学科开放基金（2018YX06）；湖南省研究生科研创新项目（CX2018B509）