目的 优化参芪强心片的提取工艺。方法 采用药效实验，以对异丙肾上腺素诱发的大鼠心力衰竭模型心脏病变改善程度为指标，初步筛选制备工艺；采用层次分析法结合单因素实验、正交试验，以固形物质量、人参皂苷Rg₁和人参皂苷Re含量，优化乙醇回流提取工艺；以固形物质量和淫羊藿苷含量为指标，优化煎煮提取工艺，并对提取工艺进行验证试验。结果 药效实验表明工艺4更优；该工艺的最佳提取条件为红参、黄芪等5味饮片加50%乙醇回流提取3次，第1次加11倍量，第2、3次加10倍量，每次2.5 h；淫羊藿等其余2味饮片煎煮提取3次，第1次加19倍量，第2、3次加16倍量，每次1.5 h。验证试验表明乙醇提取固形物得率平均值为19.78%、人参皂苷Rg₁和人参皂苷Re提取率平均值为77.52%；水提取固形物得率平均值为16.58%、淫羊藿苷提取率平均值为90.98%（RSD<2.0%，n=3）。结论 该提取工艺稳定可行。

Objective To optimize the extraction technology of Shenqi Qiangxin Tablets (SQT). Methods With the improvement of heart lesion of pharmacological model of isoproterenol induced heart failure in rats as the index, pharmacological efficacy test was used to screen extracting conditions of the technology. The extraction technology was optimized by analytic hierarchy process combined with principal component analysis, single factor and orthogonal tests using each content of solid matter, ginsenosides Rg₁, Re as indexes. And the verification test was carried out by using solid mass and icariin content as indexes. Results Pharmacological efficacy test showed that technology 4 was superior. The optimal extraction condition of technology 4 was as follow:five medicinal materials including red ginseng and astragalus were reflux extracted three times with 50% ethanol, 11 fold for the first time, 10 fold for the second and three times, 2.5 h for each extraction; Epimedium and the other two medicinal materials were decocted three times with water, 19 fold for the first time, 16 fold for the second and third times, 1.5 h for each decction. The verification test showed that the average yield of ethanol extracted solids was 19.78%, and the average extraction rate of ginsenoside Rg₁ and Re was 77.52%; The average value of water extracted solids was 16.58%, and the average extraction rate of epimedium was 90.98% (RSD < 2.0%, n=3). Conclusion The optimized extraction technology was stable and feasible.

广东省科技计划项目（2017A070701017）；广东省科技计划项目（2013B040200040）