[关键词]
[摘要]
目的 研究鲁桑Morus multicaulis枝中的化学成分。方法 采用多种色谱技术进行分离纯化,通过理化性质和波谱学数据对其进行结构鉴定。结果 从鲁桑枝90%乙醇提取物中得到6个黄酮类成分,分别鉴定为桑枝酮A(1)、carpachromene(2)、补骨脂乙素(3)、异甘草素(4)、芹菜素(5)和槲皮素(6),其中化合物1的绝对构型通过圆二色谱量子化学计算得到了确定。结论 化合物1为新化合物,命名为桑枝酮A,化合物2~4为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To investigate the chemical compounds from the twigs of Morus multicaulis. Methods The chemical constituents were isolated by various chromatographic methods from 90% ethanol aqueous extract of M. multicaulis and the structures were elucidated by a combined analysis of physicochemical properties, as well as spectroscopic methods including UV, IR, MS ECD and NMR. Results Six flavonoids were isolated and the structures were identified as moritwigsone A (1), carpachromene (2), isobavachalcone (3), isoliquiritigenin (4), apigenin (5), and quercitrin (6). The absolute configuration of compound 1 was determined by electronic circular dichroism (ECD) calculation. Conclusion Compound 1 is a new compound, named moritwigsone A, and compounds 2—4 are isolated from this plant for the first time.
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[基金项目]
广东省自然科学基金项目(2016A030313541);南方医科大学公卫学院院长基金项目(GW201832)