[关键词]
[摘要]
目的 分析中药鞣质模拟体系的膜过程污染机制。方法 以中药水提液中的鞣质和小分子药效物质(小檗碱、栀子苷)组成的模拟溶液为研究对象,考察不同模拟溶液的膜过程通量、共性高分子物质去除率、小分子药效物质透过率等指标,借助Hermia数学模型进行分析。结果 对于鞣质模拟溶液、鞣质+小檗碱+栀子苷模拟溶液,其膜通量变化和滤饼过滤模型拟合程度较高。滤饼层的形成是其通量降低和膜污染的主要原因。滤饼层的存在使得小檗碱和栀子苷透过率(分别为67.63%和87.55%)并不理想。结论 Hermia数学模型可以作为研究中药提取液膜污染机制的重要手段,滤饼层的形成和存在可能是中药提取液膜污染严重的原因之一。
[Key word]
[Abstract]
Objective To analyse the fouling mechanism of tannins simulated solution membrane process. Methods Taken the simulated solution consisting of tannins and small molecularly effective substances (berberine and geniposide) as an object of this study, the flux, the removal rate of the macromolecular substances, the size distribution of the different simulated solutions, and the was investigate by Hermia model in this study. Results For tannins simulated solution and tannins + berberine + gardenoside simulated solution, fouling occured within only one phase controlled by cake formation. Due to the presence of the cake layer, the permeation rate of berberine and geniposide was not ideal in the simulated solution (67.63% and 87.55%, respectively). Conclusion The Hermia mathematical model could be used as an important method to study the mechanism of the membrane fouling of Chinese herbal extracts. The formation and presence of the filter cake layer may be one of the reasons for the serious pollution of the traditional Chinese medicines’ membrane process.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(81274096);国家自然科学基金资助项目(81303230);国家自然科学基金资助项目(81773912);国家自然科学基金资助项目(81673610);中国工程院重点咨询研究项目(2017-XZ-08);江苏省“青蓝工程”项目