[关键词]
[摘要]
面向绿色制造的中药制药工艺路线设计,亦称“绿色设计”,其目的是极小化产品全生命周期过程的资源消耗和环境影响,协调优化经济效益和环境效益。以膜技术为核心的制药分离工艺技术与药物绿色制造息息相关,“环境、性能和成本”三大要求和成熟度、分离技术原理是制药分离工艺绿色设计的基本要素,“清洁工艺”可降低原料及能源耗损,切合“预防优于治理”的理念,也可提高企业的经济效益,对生态保护和经济建设的和谐发展具有重要保障作用。以构建膜与树脂技术系统集成为例,介绍中药制药工艺绿色设计具体实施方案,对中药制药分离工艺设计的技术经济问题开展分析和讨论。
[Key word]
[Abstract]
The Chinese materia medica pharmaceutical process route designed for green manufacturing, also known as “green design”, aims to minimize the resource consumption and environmental effect of the life cycle of products process, coordinate and optimize economic and environmental efficiency. With membrane technology at the core of the pharmaceutical separation process technology closely related to green manufacturing of drugs. The three major requirements and maturity of “environment, performance, and cost” and separation technology principle are the basic elements of the pharmaceutical separation process green design. The development and adoption of clean technology not only conforms to the “principle of precautionary superior to governance”, but also reduces the consumption of raw materials and energy, and at the same time improves the economic efficiency of the enterprises. It is the best way to protect the coordinated development of the ecological environment and economic construction. In this paper, taking the construction of “membrane and resin technology system integration” as an example, the specific implementation plan for the green design of Chinese materia medica pharmaceutical process is introduced, and the technical economical problems in the design of pharmaceutical separation process are analyzed and discussed.
[中图分类号]
[基金项目]
国家自然科学基金面上项目(81773912);国家自然科学基金面上项目(81873015);2017中国工程院咨询项目(2017-XZ-08);国家自然科学基金资助项目(81274096);国家自然科学基金资助项目(81303230);国家自然科学基金资助项目(81673610);国家发改委“国家工程研究中心”创新能力建设项目(发革办高技2011-1896);江苏省中药资源产业化过程协同创新中心分离平台建设项目(ZDXM-1-6,ZDXM-1-8)