五味子为木兰科（Magnoliaceae）五味子属Schisandra Michx.植物，在我国东南部和东北三省分布广泛。五味子主要化学成分为木脂素类、挥发油类、多糖类和有机酸类等，临床常被用于治疗2型糖尿病，疗效显著。研究显示，五味子具有抗胰岛素抵抗、抗炎、抗细胞凋亡、抗氧化应激、抑制血管病变、保护血管内皮等作用，能较好地改善糖尿病及其并发症。对近40年国内外有关五味子化学成分及其抗2型糖尿病活性研究进展进行综述，为五味子治疗糖尿病相关药物的研发提供参考。

Schisandra chinensis is a Magnoliaceae plant, widely distributed in the southeastern part of China and the three northeastern provinces. The main active ingredients of S. chinensis are lignans, volatile oil, polysaccharide, fatty acid, et al. S. chinensis is often used in the treatment of type 2 diabetes in clinical practice with remarkable curative effect. Accumulating studies showed that S. chinensis possess the pharmacological profiles of anti-insulin resistance, anti-inflammatory, anti-apoptosis, anti-oxidative stress, inhibition of vascular disease, and protection of vascular endothelium, which can improve diabetes and its complications. This paper reviews the research status of active ingredients and pharmacological effects of S. chinensis in the treatment of type 2 diabetes and its complications in the past 40 years, which provides a theoretical reference for the rational clinical promotion and new drug development of S. chinensis as a therapeutic drug for diabetes.

R282.71

缺血性心脑疾病转化医学重点实验室（三峡大学）开放基金课题（2017KXN08）