肠道菌群是一个独特的生态系统，被称为人体"被遗忘的器官"，被誉为人类的"第二基因组"。肠道菌群失调与许多中枢神经系统疾病相关，如脑卒中、帕金森病、阿尔茨海默病、精神分裂症、多发性硬化症及抑郁症等。"心与小肠相表里"是中医经典理论之一，通过阐述其理论内容及与肠道菌群间的关系，探讨肠道菌群对机体中枢神经系统疾病的重要影响，并对中药通过调控肠道菌群影响中枢神经系统，从而治疗相关疾病的潜在价值进行展望。

The gut microbiome is a unique ecosystem, which is known as the "forgotten organ" of the human body and the "second genome" of human. Gut microbiome imbalance is associated with many central nervous system diseases, such as stroke, Parkinson's disease, Alzheimer's disease, schizophrenia, multiple sclerosis, and depression. The "exterior-interior relationship between heart and small intestine" is one of the classic theories of traditional Chinese medicine. By expounding its theoretical content and its relationship with gut microbiome, the effect of gut microbiome on central nervous system diseases was discussed.

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国家行业科研专项（201507004-2）；国家国际合作基地项目（2016-65）