目的 研究神香草Hyssopus cuspidatus干燥地上部分的倍半萜类化学成分。方法 采用D101大孔吸附树脂、硅胶柱色谱、ODS、Toyopearl HW-40C、Sephadex LH-20以及半制备HPLC等方法进行分离纯化，根据理化性质以及波谱数据对化合物进行结构鉴定。结果 从神香草95%乙醇提取物中分离得到15个化合物，分别鉴定为3-eudesmene-1β-11-diol（1）、4-eudesmene-1β，11-diol（2）、1β，11-dihydroxy-5-eudesmene（3）、ent-4（15）-eudesmen-1α，11-diol（4）、7α，11-dihydroxy-cadin-10（14）-ene（5）、eudesmane-1β，5α，11-triol（6）、5-epi-eudesma-4（15）-ene-1β，6β-diol（7）、4（15）-eudesmene-1β，6α-diol（8）、（7R^*）-opposit-4（15）-ene-1β，11-diol（9）、cryptomeridiol（10）、octahydro-4-hydroxy-3α-methyl-7-methylene-α-（1-methylethyl）-1H-indene-1-methanol（11）、caryolane-1，9β-diol（12）、（3S，5R，6S，7E）-3，5，6-trihydroxy-7-megastigmen-9-one（13）、spathulenol（14）、4β，10α-aromadendranediol（15）。结论 化合物1～15均为首次从该属植物中分离得到。

Objective To study the sesquiterpenes from the aerial parts of Hyssopus cuspidatus. Methods The compounds were isolated and purified by a combination of various chromatographic techniques including D101 macroporous adsorption resin, silica gel, ODS, Toyopearl HW-40C, Sephadex LH-20, and semi-preparative HPLC. Their structures were elucidated on the basis of physicochemical properties and spectroscopic data. Results Fifteen sesquiterpenes were isolated from the 95% EtOH extracts of H. cuspidatus and their structures were elucidated as 3-eudesmene-1β-11-diol (1), 4-eudesmene-1β,11-diol (2), 1β,11-dihydroxy-5-eudesmene (3), ent-4(15)-eudesmen-1α,11-diol (4), 7α,11-dihydroxy-cadin-10(14)-ene (5), eudesmane-1β,5α,11-triol (6), 5-epi-eudesma-4(15)-ene-1β,6β-diol (7), 4(15)-eudesmene-1β,6α-diol (8), (7R^*)-opposit-4(15)-ene-1β,11-diol (9), cryptomeridiol (10), octahydro-4-hydroxy-3α-methyl-7-methylene-α-(1-methylethyl)-1H-indene-1-methanol (11), caryolane-1,9β-diol (12), (3S,5R,6S,7E)-3,5,6-trihydroxy-7-megastigmen-9-one (13), spathulenol (14), and 4β,10α-aromadendranediol (15), respectively. Conclusion Compounds 1 -15 are isolated from the plants of Hyssopus genus for the first time.

国家自然科学基金项目（31000150）；中央高校基本科研业务费项目（2016YXMS145）；波谱与原子分子物理国家重点实验室开放课题资助项目（T152602）