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[摘要]
目的 对民间丹参代用品土丹参Salvia kiaometiensis乙醇提取物进行化学成分研究。方法 采用溶剂提取法、硅胶柱、凝胶柱色谱等色谱技术进行提取分离,核磁共振、质谱等波谱技术进行结构鉴定。结果 分离得到15个化合物,主要为三萜和酚酸类化合物,分别鉴定为(2α,3α)-二羟基-3,24-异亚丙基二氧基熊果-12(13),20(29)-二烯-28-酸(1)、2α,3α-二羟基熊果-12-烯-28-酸(2)、euscaphic acid(3)、2α-羟基熊果酸(4)、山香双烯酸(5)、serrulatin E(6)、齐墩果酸(7)、3,3'-二乙氧基迷迭香酸(8)、clinopodic acid B(9)、迷迭香酸(10)、(Z,E)-2-(3,4-二羟基苯基)乙烯基酯(11)、咖啡酸(12)、咖啡酸乙酯(13)、2',4'-二羟基查耳酮(14)、4-羟基苯甲酸二十五酯(15)。结论 土丹参含有正品丹参相似的酚酸类化合物。化合物1为新熊果烷型三萜,命名为土丹参酸,所有化合物均为首次从该植物中得到。
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[Abstract]
Objective To study the chemical constituents of the roots of Salvia kiaometiensis, which was used as S. miltiorrhiza. Methods Compounds were isolated and identified by a variety of chromatographic techniques and spectroscopic methods. Results Fifteen compounds were obtained and identified as (2α,3α)-dihydroxy-3,24-(isopropylidenedioxy) urs-12(13),20(29)-diene-28-oic acid (1), 2α,3α-dihydroxyurs-12-ene-28-olic acid (2), euscaphic acid (3), 2α-hydroxyursolic acid (4), hyptadienic acid (5), serrulatin E (6), oleanolic acid (7), 3,3'-diethoxy rosmarinic acid (8), clinopodic acid B (9), rosmarinic acid (10), (Z,E)-2-(3,4-dihydroxyphenyl) ethenyl ester (11), caffeic acid (12), caffeic acid ethyl ester (13), 2',4'-dihydroxychalcone (14), and 4-hydroxy-benzoic acid pentacosyl ester (15). Conclusion S. kiaometiensis has similar phenolic acids with S. miltiorrhiza. Compound 1 is a new compound named kiaometic acid. All compounds are isolated from this plant for the first time.
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[基金项目]
国家自然科学基金资助项目(31100143)