实验性自身免疫性脑脊髓膜炎（experimental autoimmune encephalomyelitis，EAE）模型是研究人类多发性硬化（multiple sclerosis，MS）的经典动物模型，研究发现诸多天然产物具有干预EAE的作用。对近10年报道的具有干预EAE活性的生物碱类、黄酮类、萜类、多酚类等天然产物及其作用机制进行综述，为MS等神经自身免疫性疾病临床研究和治疗提供参考。

Experimental autoimmune encephalomyelitis (EAE) is a classic animal model for the study of human multiple sclerosis (MS). A number of studies have found that natural compounds possessed effects on the treatment of EAE. In this paper, we consulted related literatures, classified natural compounds such as alkaloids, flavonoids, terpenoids, and polyphenols, and explained the treatment mechanisms against EAE of Chinese materia medica, and to provide references for clinical research and treatment of neurological autoimmune diseases such as MS.

国家自然科学基金资助项目（81703782）；国家自然科学基金资助项目（81673669）；岳阳医院院级科研项目（2018YJ01）；上海市中医药新兴交叉学科"中医临床免疫学"建设项目（30304113598）