靶点是中药活性成分在体内发挥作用的基础，靶点确定是中药研发的关键，然而目前关于中药作用靶点的揭示未能获得突破性进展，已成为中药现代化进程中的瓶颈问题，因此，用于靶点研究的新思路与新技术亟需被开发。近年来，以点击化学方法为代表的基于活性蛋白质组分析技术为中药活性成分作用靶点的研究提供了新的手段。对近年来点击化学在中药活性成分靶点鉴定领域中的应用进行简要的回顾和总结，对其应用前景和发展趋势进行前瞻性的展望。

The target is the basis for the active ingredients of Chinese materia medica (CMM), which plays an important role in the patients' body. Target identification is the key work for the development of CMM. However, the current studies on the target of CMM are still limited, and it has become a bottleneck in the modernization of CMM. Therefore, new ideas and new technologies are required for the research on targets. Recently, a new method for the study of targets has been provided by the technology of activity-based protein profiling represented by click chemistry. The application of click chemistry in target identification of CMM in recent years is briefly reviewed and summarized, and the trends of application and development of click chemistry are prospected in this review.

天津市教委科研计划项目（2018KJ004）