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[摘要]
目的 研究金丝桃Hypericum monogynum地上部分的化学成分。方法 采用溶剂提取法,正、反相硅胶柱色谱及高效液相等多种色谱技术对其化学成分进行分离纯化,并根据理化性质和现代波谱技术对其进行结构鉴定。结果 从金丝桃氯仿提取物中分离得到6个化合物,分别鉴定为金丝桃素甲(1)、β-谷甾醇(2)、5α,8α-epidioxyergosta-6,22-dien-3β-ol(3)、isocudraniaxanthone B(4)、白桦脂酸(5)、2-hydroxydiplopterol(6)。结论 化合物1为新化合物,化合物3、4、6为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of Hypericum monogynum. Methods The chemical constituents were isolated and purified by solvent extraction method, the normal and reverse phase silica gel column chromatography and semi-preparative high performance liquid chromatography. Results Six compounds were isolated from the chloroform extract of H. monogynum. Their structures were identified as hypermongone A (1), β-sitosterol (2), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (3), isocudraniaxanthone B (4), betulinic acid (5), and 2-hydroxydiplopterol (6) by the physicochemical properties and modern spectroscopic methods. Conclusion Compound 1 is a new compound, and compounds 3, 4, and 6 are isolated from H. monogynum for the first time.
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[基金项目]
国家重大新药创制科技重大专项(2017Z09301060);中央高校基本科研业务费资助项目(CZP18004)