[关键词]
[摘要]
目的 对川木香属植物川木香Vladimiria souliei根的化学成分进行研究。方法 采用正相硅胶柱色谱、Sephadex LH-20柱色谱、MCI中压柱色谱、反相C18柱色谱、高效液相色谱等一系列方法对其进行分离纯化,根据其理化性质和波谱数据等对化合物结构进行鉴定,并通过单晶X-射线衍射实验,确定化合物1的绝对构型。结果 从川木香根中共分离鉴定了3个化合物,分别命名为25-羟基熊果醇(1)、川木香甾醇(2)和豆甾醇(3)。结论 化合物1和2为新化合物,化合物3为首次从川木香根中分离得到。
[Key word]
[Abstract]
Objective To study the chemical compositions from the roots of Vladimiria souliei. Methods The ethanol extract of the roots of V. souliei was isolated by silica gel, Sephadex LH-20, MCI, HPLC, and C18 reverse-phase column chromatographies. Their physical and chemical structures were elucidated by analysis of NMR and MS spectroscopic data, and the absolute configuration of compound 1 was confirmed by Cu-Kα X-ray crystallographic analysis. Results Three compounds were isolated from the roots of V. souliei, and named as 25-hydroxy-uvaol (1), vlasoudiol (2), and stigmasterol (3), respectively. Conclusion Compounds 1 and 2 are identified as new compounds, and compound 3 is isolated from the roots of V. souliei for the first time.
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[基金项目]
国家自然科学基金资助项目(81473109)