[关键词]
[摘要]
目的 研究番荔枝科鹰爪花属植物香港鹰爪花Artabotrys hongkongensis枝叶中的化学成分。方法 综合运用硅胶柱色谱、ODS柱色谱、Sephadex LH-20凝胶柱色谱以及制备型高效液相色谱等现代色谱分离方法进行系统分离,根据化合物的理化性质及其波谱学数据鉴定化合物的结构。结果 从香港鹰爪花枝叶的90%乙醇提取物中分离得到了16个化合物,分别鉴定为melilotocarpan A(1)、medicarpin(2)、5,7,8-trimethoxyflarone(3)、2'-hydroxy-3',4',6'-trimethoxychalcone(4)、piperolactam C(5)、uvarilactam(6)、artacinatine(7)、p-coumaroyl-β-phenethylamine(8)、artapilosol A(9)、大花紫玉盘醇B(10)、1,6-desoxypipoxide(11)、1β,11-dihydroxy-5-eudesmen(12)、黑麦草内酯(13)、4-hydroxy-3-methoxybenzaldehy(14)、syringlaldehyde(15)和rabdosia acid A(16)。结论 所有化合物均为首次从香港鹰爪花中分离得到,除化合物2、7和9以外,其他化合物均为首次从鹰爪花属植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from the stems and leaves of Artabotrys hongkongensis. Methods The chemical constituents of A. hongkongensis were separated and purified by silica gel, ODS, Sephadex LH-20 gel column chromatography, and preparative HPLC. Their chemical structures were identified by physicochemical properties and spectral data. Results A total of 16 compounds were isolated from the 90% ethanol extract of the stems and leaves of A. hongkongensis, which were identified as melilotocarpan A (1), medicarpin (2), 5,7,8-trimethoxyflarone (3), 2'-hydroxy-3',4',6'-trimethoxychalcone (4), piperolactam C (5), uvarilactam (6), artacinatine (7), p-coumaroyl-β-phenethylamine (8), artapilosol A (9), uvarigranol B (10), 1,6-desoxypipoxide (11), 1β,11-dihydroxy-5-eudesmen (12), loliolide (13), 4-hydroxy-3-methoxybenzaldehy (14), syringlaldehyde (15), and rabdosia acid A (16). Conclusion All compounds are isolated from A. hongkongensis for the first time. In addition to compounds 2, 7, and 9, the other compounds are isolated from the genus Artabotrys for the first time.
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[基金项目]
国家自然科学基金资助项目(31360069);国家自然科学基金资助项目(31660097);国家自然科学基金资助项目(21662011);教育部创新团队项目(IRT-16R19);海口市重点研发计划项目(2017050);药用资源化学与药物分子工程教育部重点实验室资助课题(CMEMR2014-B06)