[关键词]
[摘要]
目的 研究无花果Ficus carica果实的化学成分。方法 应用天然产物化学分离、纯化技术对无花果果实的化学成分进行分离纯化,通过波谱分析技术(MS、1H-NMR、13C-NMR)、元素分析等方法鉴定化合物的结构。结果 从无花果果实的醋酸乙酯部位中共分离得到1个新喹啉和2个新酸酐化合物,分别鉴定为4-羟基-6-甲酰氧基-8α-甲氧基-喹啉-2-酮(1)、5'β,6'α-(双二乙基)-5β,6β-环氧己烷基-环戊酐基-[2,2,1]-2α,3β-环庚烷(2)和5'β,6'β-[双-(11-甲基丁基,11'-甲基丁基)-9,9']环-8,8'-己二烯基-5α,6α-环氧己烷基-环戊酐基-[2,2,2,1]-2β,3α-环庚烷(3)。结论 3个新化合物分别命名为无花果果素K-1、无花果果素G-1和无花果果素G-2。
[Key word]
[Abstract]
Objective To investigate the chemical constituents of the fruits of Ficus carica. Methods The chemical constituents were isolated and purified with silica gel chromatography, Sephdex LH-20 and HPLC, and their structures were elucidated by spectral analysis including MS, NMR, IR spectroscopic analysis, elment analyzer, and chemical evidence. Results One new quinoline and two new anhydride compounds were isolated from ethyl acetate extract of the fruits of F. carica. The structures of the three new compounds were respectively defined as 4-hydroxyl-6-formyl-8α-methoxyl-quinoline-2-one (1), 5'β,6'α-[(di-ethyl)-5β,6β-cyclohexyl]-epoxyhexyl, cyclo-pentanhydride-[2,2,1]-2α,3β-cycloheptane (2), and 5'β,6'β-[di-(11-methylbutyl,11'-methylbutyl)-9,9']-cyclo-8'-hexadiene-5α,6α-epoxyhexyl, cyclo-pentanhydride-[2,2,2,1]-2β,3α-cycloheptane (3). Conclusion These compounds were named figine K-1, figine G-1, and figine G-2, respectively.
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[基金项目]
国家自然科学基金河南省联合基金(U1504830)