目的 对皱盖假芝Amauroderma rude子实体的化学成分进行研究，以期发现新的活性化合物。方法 运用硅胶、凝胶、MCI-gel树脂及RP-HPLC等多种色谱技术进行分离纯化，并根据理化性质和波谱数据鉴定化合物的结构。结果 从皱盖假芝子实体中分离得到了3个化合物，分别鉴定为4-乙氧基-E-3-（3，4-二羟基苯亚甲基）-5-（3，4-二羟基苯基）呋喃-2-酮（1）、七叶内酯（2）、咖啡酸（3）。结论 化合物1为新化合物，命名为皱盖假芝素A。

Objective For the purpose of finding new bioactive compounds from natural resources, the phytochemical investigation on the fruiting bodies of Amauroderma rude was carried out. Methods The chemical constituents from A. rude were isolated by various technologies, such as silica gel, Sephadex LH-20, MCI-gel resin, and high performance liquid chromatography. The isolated compounds were elucidated by spectroscopic methods, including extensive 1D, 2D NMR, and ESI-MS techniques. Results Three compounds (1-3) including a new norlignan, were isolated from this mushroom. Their structures were identified as 4-ethyoyl-E-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl) furan-2-one (1), esculetin (2), and caffeic acid (3). Conclusion Compound 1 is a new compound isolated from this fungus, which is identified as amauroderin A.

国家自然科学基金资助项目（31560099）