[关键词]
[摘要]
酸枣仁是公认的大宗中药品种之一,具有养心安神、补肝、敛汗生津之功效,是中医治疗失眠的首选药物。目前,酸枣仁化学成分研究较为清晰,其主要化学成分为黄酮类、皂苷类、生物碱类和三萜酸类等,结构丰富多样。酸枣仁化学成分的多样性决定了其生物学活性和药理作用的多样性,同时导致其药动学复杂的特性。通过对国内外文献分析与总结,梳理了酸枣仁化学成分(黄酮类、皂苷类)的药动学参数、吸收情况、组织分布特征和代谢研究成果(肠道菌群代谢转化、肝微粒体代谢转化、体内代谢转化),以期从体内过程的角度进行深度发掘和分析,为酸枣仁药效物质发现提供新的研究方向,同时为酸枣仁质量标志物的筛选和确定提供参考。
[Key word]
[Abstract]
Ziziphi Spinosae Semen (ZSS), one of the major traditional Chinese medicine varieties, has been used as a sedative medicine in China for thousands of years. The classical application of ZSS is nourishing heart and tranquilizing mind, tonifying the liver, arresting the sweat and promoting the production of the body fluid. Up to now, extensive chemical studies have also been conducted, suggesting the presence of alkaloids, flavonoids, saponins, and triterpene acids. Given the chemical diversity of ZSS, it is generally considered that the biological activity and pharmacological effect were accomplished by an array of phytochemicals. Due to complicated chemical composition of ZSS, compounds can be absorbed into circulation and then converted into even more metabolites. This review summarizes the recent advances in pharmacokinetics, absorption, and distribution, as well as biotransformation and/or metabolism of chemical compounds from ZSS, which might greatly contribute to supply the research target and scientific basis in clarifying the effective substance basis and the quality marker (Q-marker) of ZSS.
[中图分类号]
[基金项目]
国家自然科学基金青年基金项目(81603289);国家自然科学基金青年基金项目(81603251);山西省科技攻关计划-振东专项(2014ZD0306,2016ZD0105,2016ZD0104);山西省基础研究计划项目自然科学基金项目(2015011105);地产中药功效物质研究与利用山西省重点实验室(201605D111004);山西省研究生联合培养基地人才培养项目(2017JD01)