目的 研究桂枝Cinnamomi Ramulus的化学成分。方法 采用硅胶柱色谱、凝胶柱色谱、制备高效液相色谱等现代分离方法和技术对其化学成分进行分离纯化，并根据波谱数据进行结构鉴定。结果 从桂枝70%乙醇提取物中分离得到15个羧酸及其衍生物，分别鉴定为桂枝酸A（1）、二氢红花菜豆酸（2）、rel-5-（3S，8S-dihydroxy-1R，5S-dimethyl-7-oxa-6-oxobicyclo[3，2，1]-oct-8-yl）-3-methyl-2Z，4E-pentadienoic acid（3）、香草酸（4）、丁香酸（5）、对羟基苯甲酸（6）、反式肉桂酸（7）、反式邻羟基肉桂酸（8）、erythro-guaiacylglycerol-8'-vanillic acid ether（9）、水杨酸（10）、decumbic acid（11）、邻羟基苯丙酸（12）、原儿茶酸（13）、邻香豆酸葡萄糖苷（14）、cryptamygin-B（15）。结论 化合物1为新化合物，化合物2、3、9~12为首次从该植物中分离得到。

Objective To investigate the chemical constituents of Cinnamomi Ramulus.Methods Silica gel, Sephadex LH-20 column, and sp-HPLC chromatographies were applied to separate and purify the chemical constituents, followed by various spectral analyses to determine the chemical structures.Results Fifteen carboxylic acids and its derivatives were isolated, and their structures were identified as guizhi acid A (1), dihydrophaseic acid (2), rel-5-(3S,8S-dihydroxy-1R,5S-dimethyl-7-oxa-6-oxobicyclo[3,2,1]-oct-8-yl)-3-methyl-2Z,4E-pentadienoic acid (3), vanillic acid (4), syringic acid (5), 4-hydroxybenzoic acid (6), E-cinnamic acid (7), E-o-hydroxycinnamic acid (8), erythro-guaiacylglycerol-8'-vanillic acid ether (9), salicylic acid (10), decumbic acid (11), hydroxyphenylpropionic acid (12), protocatechuic acid (13), E-melilotoside (14), and cryptamygin-B (15), respectively.Conclusion Fifteen compounds were successfully identified from Cinnamomi ramulus, among which 1 is a new compound and compounds 2, 3, 9-12 are isolated from the plant for the first time.

国家自然科学基金资助项目（81773791）；上海市优秀学术带头人计划项目（16XD1403500）；上海市“中药药效物质”E-研究院项目