[关键词]
[摘要]
肿瘤转移是癌症相关死亡的主要原因。转移前微环境的形成是肿瘤转移的关键始动因素。现代药理研究显示,中药可以通过影响肿瘤分泌物抑制肿瘤转移、阻止肿瘤招募抑制性免疫细胞、影响特定组织部位基质组分的炎性极化。中药作用具有多靶点、微效、双向调节等特点,可通过影响肿瘤的功能基因网络,在调控肿瘤相关基因表达、基因的组合上发挥多因微效的整合调节作用,这与以信号转导动态网络为药物靶标的研究策略相契合。因此,通过中医药防治肿瘤转移前微环境的形成是行之有效的研究路径。对中药调控肿瘤转移微环境的现状进行综述,为中医药防治肿瘤转移的研究提供理论依据。
[Key word]
[Abstract]
Metastasis is the leading cause of cancer-related death. Pre-metastatic niche formation is the contributing factor of tumor metastasis. Traditional Chinese medicine (TCM) has a curative effect on metastasis and cancer recurrence in clinic. Modern pharmacological studies have shown that China meteria medica (CMM) can inhibit tumor metastasis by affecting tumor secretion, preventing recruitment of immune suppressive cells, and influencing anti-inflammatory polarization of matrix components in certain tissues. The regulation of CMM has the characteristics of multi-target, minor effect, and bidirection, It may play a integrate role with multi-factor and minor effect in regulating tumor-related gene expression or gene-gene combination by influencing regulating tumor-related functional gene networks. This is consistent with the research strategy of taking signal transduction dynamic network as drug target. Therefore, the prevention and treatment of pre-metastatic niche formation via TCM is an effective research strategy. This review summarizes the current research progress on regulating pre-metastasis niche by CMM, and provides a theoretical basis for the future research of TCM to prevent tumor metastasis.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(81573859);国家自然科学基金资助项目(81673725);国家自然科学基金资助项目(81673648);江苏中医药领军人才项目(SLJ0229);江苏省高校自然科学研究重大项目(17KJA360003);江苏省高校自然科学研究重大项目(18KJA360007);江苏高校品牌专业建设工程资助项目(PPZY2015A070);江苏高校中药学优势学科建设工程资助项目(PAPD)[苏政办发(2014)37号文];江苏省中药药效与安全性评价重点实验室开放课题(JKLPSE201812)