目的 研究瑞香狼毒Stellera chamaejasme中的化学成分。方法 采用多种色谱技术对瑞香狼毒95%乙醇提取物进行分离纯化，通过质谱及核磁共振等数据对化合物进行结构鉴定。结果 从瑞香狼毒提取物中分离得到了1个倍半萜类化合物，鉴定为1β，10β-二羟基愈创木-4，11-二烯-3-酮（1）。结论 化合物1为新的愈创木烷型倍半萜，命名为狼毒愈创木酮A，是首次从狼毒属植物中分离得到此类化合物。

Objective To study the chemical constituents from rhizome of Stellera chamaejasme. Methods The compound was isolated and purified by various chromatographic techniques, and its structure was elucidated by spectroscopic analysis. Results A new sesquiterpene was obtained from 95% ethanol extract of rhizome of S. chamaejasme and identified as 1β,10β-dihydroxyguaia-4,11-dien-3-one (1). Conclusion Compound 1 is a new guaiane sesquiterpene and named stelleraguaianone A. Meanwhile, the compound with a guaiane sesquiterpene skeleton is also obtained from the genus Stellera for the first time.

国家自然科学基金项目（81872761，81473590，81473119）；北京市科委G20工程创新研究项目（Z181100002218029，Z171100001717009）