目的 优化黄芪百合颗粒浸膏的减压干燥工艺，并对浸膏粉进行质量评价。方法 以干燥温度、真空度和物料厚度为自变量，以毛蕊异黄酮葡萄糖苷、橙皮苷、粗多糖和醇浸出物含量与干燥速率的综合评分为响应值，采用Box-Behnken设计-响应面法结合G1-熵权法优化黄芪百合颗粒浸膏的减压干燥工艺，并比较浸膏干燥前后的化学指纹谱相似度。以相对均齐度指数、松密度、振实密度、颗粒间孔隙率、压缩度、Hausner比、休止角、含水量和吸湿率9个物理指标对浸膏粉粉体学性质进行综合表征，建立相应的物理指纹谱，评价不同批次浸膏粉的质量一致性。结果 浸膏减压干燥的最佳工艺条件为干燥温度68 ℃，真空度0.07 MPa，物料厚度6 mm。在此条件下，浸膏减压干燥的平均综合评分为91.05，模型预测值为91.87，相对误差为0.89%，浸膏干燥前后化学指纹谱相似度均大于0.91，3批浸膏粉的化学指纹谱和物理指纹谱相似度均大于0.99。结论 优选的黄芪百合颗粒浸膏减压干燥工艺稳定、可行。

Objective To optimize the vacuum drying process of extract paste of Huangqi Baihe Granules (HBG) and evaluate the physical quality of powder. Methods With drying temperature, vacuum degree, and material thickness as independent variables, the comprehensive evaluating indexes of content of calycosin 7-O-β-D-glucopyranoside, hesperidin, crude polysaccharide, ethanol extraction amount, and drying rate as response values, Box-Behnken design-response surface methodology and G1-entropy method were used to optimize the vacuum drying process. The similarity of fingerprints between extract powder dried by the optimized technology and extract paste was compared. Additionally, the properties of powder were evaluated comprehensively with nine physical indicators, including relative homogeneity index, bulk density, tap density, interparticle porosity, compressibility, Hausner ratio, angle of repose, moisture content, and hygroscopicity. The physical fingerprint of powder were established to evaluate the quality consistency of different batches of extract powder. Results The optimal drying parameter was as follows:the drying temperature was 68℃, the vacuum degree was 0.07 MPa, the material thickness was 6 mm. Three verification experiments were carried out under these conditions and the average comprehensive evaluating indexes of vacuum drying was 91.05, which was close to the model prediction 91.87, and the relative error was 0.89%. Compared with the extract paste, the similarity of fingerprint of extract powder were more than 0.91. The similarity of chemical and physical fingerprint of three batches of extract powder were higher than 0.99. Conclusion The optimized vacuum drying technology of extract paste of HBG is stable and feasible.

甘肃省科技支撑计划项目（120FKCA169）；甘肃中医药大学中青年科研基金项目（ZQ2015-9）；甘肃省中药新产品创制工程实验室开放基金项目（ZYFYZH-KJ-2015-001）