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[摘要]
目的 研究百尾参Disporum cantoniense的化学成分。方法 通过大孔树脂、十八烷基硅烷键合硅胶(ODS)、Sephadex LH20、MCI-gel CHP20树脂反复柱色谱及制备HPLC方法分离纯化并通过波谱分析鉴定百尾参的化学成分。结果 从百尾参中分离得到20个化合物,分别鉴定为邻羟基苯甲醇(1)、对羟基苯甲醛(2)、对羟基苯乙酮(3)、丁香醛(4)、覆盆子酮(5)、新甘草苷(6)、2,3,5,4′-四羟基二苯乙烯-2-O-β-D-葡萄糖苷(7)、反式-1-(4′-羟基苯基)-丁-1-烯-3-酮(8)、异槲皮苷(9)、3-羟基-1-(4-羟基-3,5-二甲氧基苯基)-1-丙酮(10)、icariol A2(11)、蜕皮激素(12)、glansreginic acid(13)、橙皮苷(14)、芒柄花苷(15)、槲皮素(16)、异鼠李素-3-O-β-D-葡萄糖苷(17)、(E)-4-(4-hydroxy-3-methoxyphenyl) but-3-en-2-one(18)、(-)-secoisolariciresinol(19)、木犀草素(20)。结论 化合物1、3~8、10~15、17~19为首次从该属植物中分离得到。
[Key word]
[Abstract]
Objective To investigate the chemical constituents from Disporum cantoniense. Methods Compounds were isolated and purified by macroporus resin, ods, Sephadex LH-20, MCI-gel CHP20 resin column chromatography and preparative HPLC. The structures were identified by spectral analysis. Results Twenty compounds were isolated and identified as 2-hydroxybenzyl alcohol (1), p-hydroxybenzaldehyde (2), 4-hydroxyacetophenone (3), 3,5-dimethoxy-4-hydroxy-benzaldehyde (4), 4-(4-hydroxyphenyl)-2-butanone (5), neoliquiritin (6), 2,3,5,4'-tetrahydroxy stilbene-2-Ο-β-D-glucoside (7), (E)-1-(4'-hydroxyphenyl)-but-1-en-3-one (8), isoquercitrin (9), 3-hydroxy-1-(4-hydroxy-3,5-dimethoxy-phenyl)-1-propanone (10), icariol A2 (11), ecdysterone (12), glansreginic acid (13), hesperidin (14), ononin (15), quercetin (16), isorhamnetin-3-O-β-D-glucoside (17), (E)-4-(4-hydroxy-3-methoxyphenyl) but-3-en-2-one (18), (-)-secoisolariciresinol (19), and luteolin (20). Conclusion Compounds 1, 3-8, 10-15, and 17-19 are isolated from the genus of Disporum for the first time.
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[基金项目]
江西省杰出青年资助计划项目(20162BCB23003,20142BCB23022);江西省创新驱动"5511"工程项目优势科技创新团队(20165BCB19009);江西省百千万人才工程资助[赣人社字(2016)332号];南昌市优势科技创新团队[洪科字(2016)173号]