目的 采用超高效液相色谱-四级杆-静电场轨道阱（UPLC-Q-Exactive Orbitrap-MS），对宣木瓜饮片的化学成分进行快速识别和鉴定。方法 采用Halo C₁₈（100 mm×2.1 mm，2.7 μm）色谱柱，0.05%甲酸水溶液（A）-0.05%甲酸的乙腈溶液（B）为流动相，梯度洗脱，体积流量0.3 mL/min，柱温40℃，正、负离子模式扫描。结果 共鉴定出宣木瓜饮片中25种化学成分。包括游离氨基酸5种、有机酸类11种、糖苷类2种、黄酮3种和三萜4种。结论 该法可准确、快速地对宣木瓜饮片中化学成分进行定性分析，为阐明宣木瓜药效物质基础和优选质量控制指标提供科学依据。

Objective An ultra-high performance liquid chromatography coupled with hybrid quadrupole-orbitrap mass spectrometry (UPLC-Q-Exactive Orbitrap-MS) method was developed to rapidly analyze and identify the chemical constituents from the fruit of Chaenomeles speciosa. Methods The analysis was performed on a Halo C₁₈ column (100 mm×2.1 mm, 2.7 μm) by gradient elution. The mobile phase consisted of 0.05% formic acid-acetonitrile and 0.05% formic acid-water at a flow rate of 0.3 mL/min. The column temperature was at 40℃. The information of the compounds was acquired in positive and negative mode. Results Totally 25 compounds were identified, including five kinds of free amino acids, 11 organic acids, two glycosides, three flavonoids, and four triterpenes. Conclusion The established method is accurate, rapid, and sensitive, which provides a reference for further clarifying the material basis of its efficacy and the selection of quality control indicators.

国家公益性行业科研专项：30种中药饮片产地加工与炮制生产一体化关键技术规范研究——宣木瓜（201507002-2）；山东省自然科学基金项目（ZR2015PH009）