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[摘要]
目的 探讨疏风解毒胶囊抗炎作用机制。方法 采用肺炎链球菌致大鼠肺炎模型,观察疏风解毒胶囊给药后对细菌计数、白细胞(WBC)计数及分类、肺组织病理学及炎症反应相关因子:补体C3(C3)、缓激肽(BK)、单核细胞趋化因子(MCP-1)、核转录因子-κB(NF-κB)、环氧化酶1(COX-1)、COX-2的影响。结果 疏风解毒胶囊能显著降低模型大鼠外周血、肺泡冲洗液中细菌数量与外周血WBC数量,显著减轻肺组织炎细胞浸润及降低血清NF-κB、MCP-1、炎症介质BK和COX-2水平。结论 疏风解毒胶囊有显著的体内杀菌与抗炎作用,其通过降低WBC数量,降低血清转录因子NF-κB、趋化因子MCP-1、炎症介质BK及COX-2水平对肺炎模型大鼠有显著的治疗作用。
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[Abstract]
Objective To explore the anti-inflammatory mechanism of Shufeng Jiedu Capsules (SJC). Methods The Streptococcus pneumoniae (SP)-induced pneumonia model of rats was used to study the anti-inflammation of SJC. The factors related to inflammatory response from the blood plasma such as leukocyte count and its classification, complement C3, bradykinin (BK), monocyte chemotactic protein (MCP-1), NF-κB, COX-1, COX-2, and bacterial count were measured after the administration of SJC. Results SJC significantly decreased the bacterial count in peripheral blood and BALF, and leukocyte in peripheral blood; It also significantly reduced the levels of NF-κB, MCP-1, BK, and COX-2 in serum. Conclusion SJC has significant sterilization and anti-inflammation effects, which shows significantly therapeutic effect on pneumonia model rats by reducing the levels of NF-κB, MCP-1, BK, and COX-2.
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