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[摘要]
目的 研究小驳骨Gendarussa vulgaris地下茎的化学成分。方法 采用硅胶柱色谱、凝胶色谱等方法进行化学成分的分离纯化,通过理化性质和波谱数据进行结构鉴定。结果 从小驳骨地下茎的乙醇提取物分离得到了16个化合物,分别鉴定为胡萝卜苷(1)、6"-O-acetylisavitexin(2)、9,10-dihydroxy-4,7-megastigmadien-3-one(3)、22E,24R-ergosta-7,22-diene-3β,5α,6β,9α-tetraol(4)、异鼠李素(5)、槲皮素(6)、刺五加苷E(7)、gusanlung A(8)、gusanlung B(9)、桦木醇(10)、异牡荆黄素-2"-O-鼠李糖苷(11)、异牡荆黄素(12)、芫花素(13)、芹菜素(14)、槲皮素-3-O-β-D-葡萄糖醛酸苷(15)、2-(4-hydroxy-3-methoxyphenyl)-3-(2-hydroxy-5-methoxyphenyl)-3-oxo-1-propanol(16)。结论 化合物3、5、11、12、15均为首次从该植物中分离得到,其中化合物2、4、13、16为首次从该属植物中分离得到。
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[Abstract]
Objective To study the chemical constituents of Gendarussa vulgaris. Methods The chemical constituents were isolated and purified with silica column chromatography and gel chromatography, etc. Their structures were identified by physico-chemical properties and various spectroscopic methods including NMR spectrum, MS, UV, etc. Results A total of 16 compounds were isolated and elucidated as daucosterol (1), 6"-O-acetylisavitexin (2), 9,10-dihydroxy-4,7-megastigmadien-3-one (3), 22E,24R-ergosta-7,22-diene-3β,5α,6β,9α-tetraol (4), isorhamnetin (5), quercetin (6), eleutheroside E (7), gusanlung A (8), gusanlung B (9), betulin (10), isovitexin-2"-O-rhamnoside (11), isovitexin (12), genkwanin (13), apigenin (14), quercetin 3-O-β-D-glucuronide (15), and 2-(4-hydroxy-3-methoxyphenyl)-3-(2-hydroxy-5-methoxyphe-nyl)-3-oxo-1-propanol (16). Conclusion Compounds 3, 5, 11, 12 and 15 are isolated from G. vulgaris for the first time. Compound 2, 4, 13, and 16 are isolated from the plant of genus for the first time.
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[基金项目]
湖南省重点建设学科经费资助项目(2011-42)