[关键词]
[摘要]
中药质量是影响中医药传承和发展的重要因素,然而由于中药成分的复杂性和复方应用的特殊性,现今的中药质量标准存在难以保障临床疗效的问题。刘昌孝院士提出中药质量标志物的概念和基本属性,为中药质量标准研究指明了方向。中医方证代谢组学是整合了中药血清药物化学与代谢组学技术,在方证对应并显效的情况下,发现与临床疗效相关、体现方剂配伍、可追溯体内代谢和制备过程的中药药效物质基础的研究策略,是发现中药质量标志物的有效方法。利用中医方证代谢组学方法已经对茵陈蒿汤、六味地黄丸等方剂及男仕胶囊、AS1350等中药保健品质量标志物的发现研究进行了探索。
[Key word]
[Abstract]
The quality of Chinese materia medica (CMM) has become an important factor affecting the inheritance and development of traditional Chinese medicine. However, due to the complexity of CMM ingredients and the specificity of prescription application, the current quality standards of CMM are difficult to guarantee clinical efficacy. Academician Changxiao Liu proposed the concept of the quality marker (Q-marker) of CMM and its basic attributes, which provided a direction for the study of CMM quality standards. Chinmedomics, integrating serum pharmacochemistry and metabolomics technology, under the conditions of correspondence of prescription-syndrome with therapeutic effect, can be used to find the Q-markers of CMM which are related to the clinical efficacy, and reflect the compatibility of prescriptions, and trace the in vivo metabolism and preparation process. The research strategy based on Chinmedomics is an effective method for discovering the Q-markers of CMM, it has been applied to discovery Q-markers of Yinchenhao Decoction, Liuwei Dihuang Pill, NanShi Capsule, AS1350, and other CMM formula as well as the health products.
[中图分类号]
[基金项目]