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[摘要]
目的 研究蒙药山沉香(羽叶丁香Syringa pinnatifolia去皮的根和枝干)的化学成分。方法 运用溶剂法及多种柱色谱分离技术进行系统分离,利用理化鉴别及现代波谱技术鉴定化合物的结构。结果 从山沉香醋酸乙酯部位和正丁醇部位中分离得到21个化合物,分别鉴定为O-乙基荜澄茄素(1)、山沉香酮B(2)、3β-乙酰氧基-11α,12α-环氧-齐墩果烷-28,13β-内酯(3)、松柏醛(4)、(8R,8'R,9S)-荜澄茄素(5)、异香草酸(6)、(+)-二氢荜澄茄素(7)、6,10-环氧-4α-羟基-愈创木烷(8)、(+)-1β,4β,6α-三羟基桉叶烷(9)、麻栎木脂素B(10)、2-亚胡椒基-3-胡椒基-1,4-丁二醇(11)、4,4'-二羟基-3,3',9'-三甲氧基-9,9'-环氧木脂素(12)、2β-羟基-α-杜松醇(13)、杜松烷-4β,5α,10α-三醇(14)、落叶松萘酮(15)、落叶松脂素(16)、4,4'9-三羟基-3,3'-二甲氧基-9,9'-环氧木脂素(17)、(−)-开环异落叶松树脂酚-9,9'-缩丙酮(18)、berchemol(19)、胡萝卜苷(20)、开环异落叶松树脂醇(21)。结论 化合物1 、7 ~10 、13 、14 和18 为首次从丁香属植物中分离得到,3 和20 为首次从该种植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical components from Mongolian medicinal materials Ramulus syringae (the peeled roots and branches of Syringa pinnatifolia). Methods The compounds were purified by column chromatography on silica gel, ODS, and Sephadex LH-20. Their structures were elucidated on the basis of spectroscopic methods. Results Twenty-one compounds were isolated from R. syringae and their structures were identified as O-ethylcubebin (1), pinnatifone B (2), 3β-O-acetyl-11α,12α-epoxy-oleanan-28,13β-olide (3), coniferyl aldehydel (4), (8R,8'R,9S)-cubebin (5), isovanillic acid (6), (+)-dihydrocubebin (7), 6,10-eposoy-4α-hydroxy guaiane (8), (+)-1β,4β,6α-trihydroxyl-eudesmane (mucrolidin, 9), acutissimalignan B (10), 2-piperonylidene-3-piperonyl-1,4-butanediol (11), 4,4'-dihydroxy-3,3',9'-triMethoxy-9,9'-epoxylignan (12), 2β-hydroxy-α-cadinol (13), cadinane-4β,5α, 10α-triol (14), larixnaphthanoe (15), lariciresinol (16), 4,4'9-trihydroxy-3,3'-dimethoxy-9,9'-epoxylignan (17), (−)-secoisolariciresino-9,9'-acetonide (18), berchemol (19), daucosterol (20), and ecoisolariciresinol (21). Conclusion Compounds 1, 7, 8, 9, 10, 13, 14, and 18 are isolated from the genus Syringa for the first time. Compounds 3 and 20 are isolated from S. pinnatifolia for the first time.
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[基金项目]
内蒙古自治区草原英才工程项目(内组通字[2014]27号);内蒙古自治区草原英才滚动支持项目(内组通字[2017]19);内蒙古医科大学青年创新基金(qncx201501)