[关键词]
[摘要]
目的 研究民间药用植物云实Caesalpinia decapetala种子的化学成分。方法 采用硅胶、Sephadex LH-20等柱色谱技术对云实种子的乙醇提取物进行前处理,运用半制备高效液相进行分离制备,根据NMR、ESI-MS、CD等波谱数据鉴定化合物结构。结果 从云实种子的氯仿部位浸膏中分离得到了8个卡山烷二萜类化合物,分别鉴定为1α,6α,7β-triacetoxy-14α-methoxy-vouacapen-5α-ol(1)、caesalmin F(2)、neocaaesalpin MP(3)、1-deacteoxy-1-oxocaesalmin C(4)、neocaesalpin AA(5)、bonducellpin C(6)、bonducellpin E(7)、neocaaesalpin N(8)。结论 化合物1 为1个新化合物,命名为云实二萜A,化合物1 和2 为1对C-14位差向异构体;化合物3 ~7 为首次从云实种子中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from the medicinal herb of Caesalpinia decapetala. Methods Silica gel and Sephadex LH-20 column chromatography techniques were used as pretreatments for ethanol extract of the seeds of C. decapetala, and then semi-preparative HPLC technique was used. Results Eight cassane diterpenes were isolated from the chloroform extract of C. decapetala. According to NMR, ESI-MS, and CD spectrum data, they were identified as 1α,6α,7β-triacetoxy-14α-methoxy-vouacapen-5α-ol (1 ), caesalmin F (2), neocaaesalpin MP (3), 1-deacteoxy-1-oxocaesalmin C (4), neocaesalpin AA (5), bonducellpin C (6), bonducellpin E (7), and neocaaesalpin N (8). Conclusion Compound 1 is a new compound and named as caediterpene A, compound 1 —2 are a pair of epimeric diterpenes, and compounds 3 —7 are obtained for the first time from the seeds of C. decapetala.
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[基金项目]
湖南省教育厅优秀青年项目(16B213);中药饮片质量保障系统研究(一)项目(201507002);湖南省重点学科建设项目(JSU0713);吉首大学科研平台开放基金项目(JSK2017YX008)