橙皮素是一种从芸香科柑橘属植物果实中提取的二氢黄酮类化合物，其具有多种药理活性，包括抗菌、抗炎、抗氧化、抗病毒、抗变态反应、调节血脂及增强免疫等。近年来，有研究报道橙皮素及其衍生物还具有抗阿尔茨海默病、抗帕金森病、降血糖、抗蛇毒血凝酶、抗纤维化等作用。对近5年来有关橙皮素及其衍生物一些新的药理作用研究进行综述，以期为橙皮素的进一步开发利用提供参考，使其在其他疾病领域发挥更好的疗效。

Hesperetin is a dihydrogen flavonoid extracted from the Citrus fruits of the Rutaceae plants. It has many pharmacological effects, such as antibacterial, anti-inflammatory, anti-oxidant, antiviral, anti-allergy, regulating blood lipid, enhancing immunity, etc. In recent years, it is reported that hesperetin and its derivatives had anti-Alzheimer's disease, anti-Parkinson's disease, antihyperglycemic effect, inhibiting the venom thrombin, anti-fibrosis, ect. This paper mainly reviews some new pharmacological effects of hesperetin and its derivatives in the past five years, aiming to provide reference for further development and utilization of hesperidin and make it achieve better curative effect in other diseases.