奥沙利铂是第3代铂类抗肿瘤药物，具有疗效好、抗癌谱广泛等优点。但周围神经病变是其主要的剂量限制性毒性，影响患者的治疗进程和生活质量。以中医理论为指导的益气活血、温阳通络等传统中药在治疗此症上取得一定进展。从中药复方及活性成分两方面对国内外研究进展予以综述，为临床医师治疗奥沙利铂神经毒性提供依据。

Oxaliplatin is the third generation of platinum antitumor drugs, which has the advantages of good efficacy, broad anticancer spectrum and so on. However, peripheral neurotoxicity is the main dose limiting toxicity, which affects not only its clinical application but also the quality of patients' life. According to Chinese medicine theory, some progress has been made in the treatment of this disease by using the traditional herb with invigorating qi and activating blood and warming yang for removing obstruction in collaterals. This article summarizes the literatures in domestic and foreign countries from the aspects of Chinese prescription and active ingredients, which provides basis for clinicians to treat the neurotoxicity of oxaliplatin.

国家自然科学基金资助项目（81773904，81473351）；黑龙江中医药大学科研基金项目（201720）