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[摘要]
目的 研究黄花蒿Artemisia annua全草大极性部位的化学成分。方法 采用Sephadex LH-20柱色谱、硅胶柱色谱、ODS柱色谱和制备薄层色谱等方法进行分离纯化,根据波谱数据确定化合物的结构。结果 从黄花蒿70%乙醇冷浸提取物的甲醇可溶部位中共分离得到14个化合物,分别鉴定为黄花蒿苷A(1)、东莨菪苷(2)、2,4-二羟基-6-甲氧基苯乙酮-4-O-β-D-吡喃葡萄糖苷(3)、咖啡酸甲酯(4)、水杨酸(5)、阿魏酸(6)、香草酸(7)、2,4-二羟基-6-甲氧基苯乙酮(8)、高圣草酚(9)、棕鳞矢车菊黄酮素(10)、penduletin(11)、甲氧基寿菊素(12)、圣草酚(13)和(R)-15,16-didehydrocoriolic acid(14)。结论 化合物1为未见文献报道的新香豆素苷;化合物14为首次从蒿属植物中分离得到;化合物9为首次从黄花蒿中得到。
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[Abstract]
Objective To study the chemical constituents with high polarity from the whole herb of Artemisia annua. Methods The constituents were isolated and purified by column chromatography on Sephadex LH-20, silica gel, ODS, and preparative TLC. The structures were elucidated by the analysis of the spectroscopic data. Results Fourteen compounds were obtained from the methanol soluble fraction of the 70% ethanol extract of A. annua by maceration at room temperature and identified as artemisiannuside A (1), scopolin (2), 2,4-dihydroxy-6-methoxyacetophenone-4-O-β-D-glucopyranoside (3), methyl caffeate (4), salicylic acid (5), ferulic acid (6), vanillic acid (7), 2,4-dihydroxy-6-methoxyacetophenone (8), homoeriodictyol (9), jaceidin (10), penduletin (11), axillarin (12), eriodictyol (13), and (R)-15,16-didehydrocoriolic acid (14), respectively. Conclusion Compound 1 is a new acylated coumarin glycoside. Compound 14 is isolated from the Artemisia genus for the first time and compound 9 is firstly isolated from A. annua.
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