[关键词]
[摘要]
中药制剂由于其原料组分极易吸湿常发生吸湿过量的情况,含水量的提高易导致制剂稳定性减弱,同时使产品的成型难度增加。目前可用吸附理论、毛细管凝结理论、Fick扩散定理等阐述吸湿的基本原理,并采用多种评价指标判断吸湿程度,以此作为依据发展出多种中药制剂防潮技术。查阅近年来的相关文献,并结合具体实践总结目前普遍通行的吸湿原理、表征方法及可行的防潮技术,为中药制剂的防潮提供技术参考。
[Key word]
[Abstract]
Excessive moisture absorption often occurs in Chinese material medica (CMM) preparations due to its raw material composition is easy to absorb moisture, the increases of water content easily weaken the stability of the preparations and increase the molding difficulty of the products at the same time. At present, the basic principle of moisture absorption can be explained by adsorption theory, theory of capillary condensation, and Fick diffusion theorem, combining a variety of evaluation indexes to judge the degree of moisture absorption, which can be as the basis for developing different moisture-proof technology of CMM preparations. The relevant literatures in recent years were reviewed in this paper, conbined with the widely recognized principle of moisture sorption, characterization method, and feasible moisture-proof technology, aiming to provide technical reference and implementation examples for the moisture-proof of CMM preparations.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(81503259);江苏省自然科学基金资助项目(BK20151002);中国科协青年人才托举工程项目(CACM-2017-QNRC1-01);江苏省研究生科研与实践创新计划项目(KYLX16_1158);南京中医药大学大学生实践创新训练计划项目(201710315067Y);江苏高校优势学科建设工程项目(PAPD)