[关键词]
[摘要]
生物药剂学分类系统(biopharmaceutics classification system,BCS)是一种根据药物的溶解性和渗透性高低,对药物进行科学分类的研究方法,多适用于单一成分的口服化学药品。相比大多数化学药,中药具有多成分复杂体系,因此BCS在中药研究中具有一定的局限性。基于BCS科学框架,国内学者陆续提出中药相关BCS。结合国内外相关文献,对中药相关BCS的发展、测定方法以及应用进行综述,以期为中药相关BCS的深入研究奠定基础。
[Key word]
[Abstract]
Biopharmaceutics classification system (BCS) is a research method that scientifically classifies drugs based on its solubility and permeability, which is generally applicable to oral chemical products of single-component. Compared with most western medicines, Chinese materia medica (CMM) has a complex system of multiple components, so BCS has certain limitations in the study of CMM. Based on the scientific framework of BCS, domestic scholars have successively proposed some BCS for CMM. This article reviews the development, determination, and application of BCS for CMM by consulting relevant domestic and foreign literatures, in order to lay a reference for the in-depth research of BCS for CMM.
[中图分类号]
[基金项目]
北京市科委课题(Z161100001816013,Z171100001717012)