[关键词]
[摘要]
D-葡聚糖是一类免疫多糖,可调节机体免疫力,是一种重要的生物效应调节剂。羧甲基葡聚糖(carboxymethylated glucan,CMG)是D-葡聚糖的羧甲基衍生物,具有良好的水溶性和免疫活性。因此,在抗肿瘤治疗中具有广阔的应用前景。对CMG的抗肿瘤作用及其机制方面的研究进展进行综述,为CMG作为防治抗肿瘤药物的开发利用提供科学依据。
[Key word]
[Abstract]
D-glucan, an immune polysaccharide, is one kind of vital biological response modifiers (BRMs) which has the function of immune regulation. Carboxymethyl-glucan (CMG) is a water-soluble derivative of D-glucan that possesses excellent immunocompetent and water-solubility. Therefore, it has broad application prospects in anticancer therapy. The research progress of antitumor effect and mechanism of CMG was reviewed in this paper, which provides a scientific basis for the development and utilization of CMG as a candidate for the prevention and treatment of cancer.
[中图分类号]
[基金项目]
辽宁省教育厅一般项目(L2015522);沈阳药科大学科研专项基金(QNJJ2014504)