[关键词]
[摘要]
建立科学的中药质量控制与评价方法是保障中药安全、有效的关键点和难点。现有的中药质量控制与评价方法存在诸多的局限性,不能实现真正意义上的有效评价。在现有中药质量评价体系的基础上,结合生物效应评价方法,能实现中药质量控制及评价的科学性,为中药的现代化提供必要的技术支持。对生物效应评价法的特点、优势及构建进行了分析与总结,归纳了具有活血化瘀、宣肺及抑菌、抗炎等生物活性中药的生物效应评价方法,为建立科学的中药质量控制与评价方法提供借鉴。
[Key word]
[Abstract]
Establishing a scientific method of quality control and evaluation of Chinese materia medica (CMM) is important and challenging for ensuring the safety and effectiveness of CMM. The existing methods of quality control and evaluation of CMM have many limitations and it can not be effectively evaluated in the true sense. Based on the existing CMM quality system, the rational use of bioeffect evaluation method can realize the scientific quality control and evaluation of CMM and provide the necessary technical support for the modernization of CMM. This article summarizes the bioeffect evaluation methods established in CMM, such as activating blood and removing stasis, ventilating lung, antibacterial activity, and anti-inflammatory activity. This paper provides useful reference for establishing a scientific quality control and evaluation system of CMM.
[中图分类号]
[基金项目]
国家自然科学基金面上项目:鹿源BVDV E2的优化基因与布氏杆菌主要保护性抗原的融合基因在BCG中的共表达及rBCG免疫原性研究(31372436);吉林省科技厅科技支撑计划:梅花鹿鹿茸质量综合评价体系及污染检测关键技术研究(20160209006YY);国家自然科学青年基金:氨基酸衍生化法提高抗BVDV活性成分黄芩苷生物利用度的研究(31502109)