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[摘要]
目的 研究平卧菊三七Gynura procumbens(Lour.) Merr.全草的化学成分。方法 采用硅胶、Sephadex LH-20、反相ODS等技术进行分离纯化;通过理化性质、核磁、质谱等方法鉴定化合物结构。结果 从平卧菊三七乙醇提取物中分离得到了27个化合物,分别鉴定为邻苯二甲酸二丁酯(1)、熊果酸(2)、山柰酚-3-O-β-D-葡萄糖苷(3)、5-hydroxymaltol (4)、对羟基苯甲酸(5)、4-氨基肉桂酸(6)、(E)-2-hexenyl β-D-glucoside (7)、1-(3-indolyl)-2,3-dihydroxy-propan-1-one (8)、山柰酚-7-O-β-D-葡萄糖苷(9)、槲皮素-3-O-β-D-吡喃葡萄糖苷(10)、3,4,5-三咖啡酰基奎宁酸甲酯(11)、芦丁(12)、橙皮苷(13)、3,4-dihydroxyphenylacetic acid methyl ester (14)、刺梨酸(15)、委陵菜酸(16)、2-methoxy-4-(2-propenyl)-phenyl-O-β-D-glucopyranoside (17)、negletein (18)、没食子酸-3-甲基醚(19)、caesalpiniaphenol D (20)、2,5-二羟基苯甲酸(21)、原儿茶醛(22)、isohematinic acid (23)、icariside B1(24)、dendranthemoside B (25)、4-甲氧基肉桂酸(26)、黄芩苷(27)。结论 化合物4、6~9、11、13~27为首次从菊三七属植物中分离得到,化合物1、2、10和12为首次从平卧菊三七中分离得到。
[Key word]
[Abstract]
Objective To investigate the chemical constituents from the whole plants of Gynura procumbens.Methods The chemical constituents were isolated and purified by silica gel, Sephadex LH-20, and ODS. Their structures were determined by physicochemical properties and spectroscopic analysis.Results Twenty-seven compounds were identified as dibutyl phthalate (1), ursolic acid (2), kaempferol 3-O-β-D-glucopyranoside (3), 5-hydroxymaltol (4), 4-hydroxylbenzoic acid (5), 4-aminocinnamic acid (6), (E)-2-hexenyl β-D-glucoside (7), 1-(3-indolyl)-2,3-dihydroxy-propan-1-one (8), kaempferol-7-O-β-D-glucoside (9), quercetin-3-O-β-D-glucopyranoside (10), 3,4,5-tri-caffeoylquinic acid methyl ester (11), rutin (12), hesperidin (13), 3,4-dihydroxyphenylacetic acid methyl ester (14), euscophic acid (15), tormentic acid (16), 2-methoxy-4-(2-propenyl)-phenyl-O-β-D-glucopyranoside (17), negletein (18), 4,5-dihydroxy-3-methoxybenzoic acid (19), caesalpiniaphenol D (20), gentisic acid (21), 3,4-dihydroxybenzaldehyde (22), isohematinic acid (23), icariside B1 (24), dendranthemoside B (25), 4-methoxycinnamic acid (26), and baicalin (27).Conclusion Compounds 1, 2, 10, and 12 are obtained from the plants of G. procumbens for the first time, and compounds 4, 6-9, 11, 13-16, and 17-27 are obtained from Gynura genus for the first time.
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[基金项目]
江西省5511优势科技创新团队-创新药物及制剂体内过程评价研究(20165BCB19009);南昌市科技计划-药物代谢动力学知识创新团队(赣科字[2016]173号);江西省自然科学基金资助项目(2016BAB205194);江西中医药大学重点学科建设基金(51513039/5151400236)