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[摘要]
目的 研究壮药三角泡(倒地铃Cardiospermum halicacabum干燥全草)的化学成分。方法 通过硅胶、聚酰胺、凝胶等柱色谱及重结晶方法进行分离和纯化,根据理化性质和波谱数据对化合物结构进行鉴定。结果 从三角泡正丁醇部位分离13个化合物,分别鉴定为金圣草黄素-7-O-β-D-葡萄糖醛酸苷丁酯(1)、金圣草黄素-7-O-β-D-葡萄糖醛酸苷乙酯(2)、金圣草黄素-7-O-β-D-葡萄糖醛酸苷甲酯(3)、金圣草黄素(4)、芹菜素-7-O-β-D-葡萄糖醛酸苷丁酯(5)、芹菜素-7-O-β-D-葡萄糖醛酸苷乙酯(6)、芹菜素-7-O-β-D-葡萄糖醛酸苷甲酯(7)、芹菜素-7-O-β-D-葡萄糖苷(8)、芹菜素(9)、木犀草素-7-O-β-D-葡萄糖醛酸苷甲酯(10)、木犀草素-7-O-β-D-葡萄糖醛酸苷(11)、木犀草素(12)、槲皮素(13)。结论 化合物1~3为新的黄酮类化合物,分别命名为倒地铃苷D、倒地铃苷B和倒地铃苷A;化合物5~8、10、11为首次从该属植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of Zhuang medicine Cardiospermum halicacabum.Methods The compounds were isolated and purified by silica gel, polyamide gel, and Sephadex LH-20 chromatography. The structures of the compounds were identified on the basis of chemical and spectral methods.Results Thirteen compounds were isolated from the butanol extracts of C. halicacabum and identified as chrysoeriol-7-O-β-D-glucuronide butyl ester (1), chrysoeriol-7-O-β-D-glucuronide ethyl ester (2), chrysoeriol-7-O-β-D-glucuronide methyl ester (3), chrysoeriol (4), apigenin-7-O-β-D-glucuronide butyl ester (5), apigenin-7-O-β-D-glucuronide ethyl ester (6), apigenin-7-O-β-D-glucuronide methyl ester (7), apigenin-7-O-β-D-glucuronide (8), apigenin (9), luteolin-7-O-β-D-glucuronide methyl ester (10), luteolin-7-O-β-D-glucuronide (11), luteolin (12), and quercetin (13).Conclusion Compounds 1, 2, and 3 are new flavonoiels named as cardiosperoside D, cardiosperoside B, and cardiosperoside A. Compounds 5-8, 10, and 11 are isolated from this genus for the first time.
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[基金项目]
广西自然科学基金项目(2014GXNSFAA118213);广西高校科学技术研究项目(ZD2014071);广西高校中药提取纯化与质量分析重点实验室(桂教科研[2014]6号);广西中医药大学2017年杨世林教授团队人才培养建设项目(YSL17017)