目的 研究不同干燥方式对丹参浸膏粉体学性质的影响。方法 以丹参提取物为模型药物，通过减压干燥、真空微波干燥及喷雾干燥得到3种浸膏粉，以粒径、粒径分布宽度、粒径范围、松密度、振实密度、豪斯纳比率、休止角、压缩度、黏性、比表面积、孔体积、含水量和吸湿性13个物理指标综合评价粉体学性质，并将粉体物理属性归纳为均一性、堆积性、流动性、可压性和稳定性5个方面，建立相应的物理指纹谱。通过物理属性数值评价粉体学性质；运用相似度评价法比较3种粉体的相似度；构建参数指数、参数轮廓指数以及良好可压指数，用于分析粉末的可压性。结果 3种干燥方式所得粉体均具有较差的流动性和稳定性，其中减压干燥和真空微波干燥粉体具有良好的堆积性，喷雾干燥粉体具有优越的均一性和可压性；由相似度可知，喷雾干燥与减压干燥浸膏粉体学性质相似度为79%，与真空微波干燥的相似度为81.3%。结论 中药物理指纹谱可用于评价不同干燥方式对中药提取物粉体学性质的影响，以及物理性质对药物成型性的影响，为中药浸膏粉体提供了新的评价模式。

Objective To study the influence of different drying technology on the micromeritic properties of Salvia miltiorrhiza extract powder.Methods Taking S. miltiorrhiza extract as model drug, three kinds of extract powders were obtained by vacuum drying, vacuum microwave drying, and spray drying. The properties of powder were evaluated comprehensively with 13 physical indicators, including particle size, span, width, bulk density, tap density, Hausner ratio, angle of repose, compressibility, viscosity, specific surface area, pore volume, moisture content and hygroscopicity. Furthermore, the physical properties of the powder were summarized as homogeneity, stackability, fluidity, compressibility and stability of five aspects, then established the corresponding physical fingerprint spectrum. The powder properties were evaluated by the physical property values. The similarity of the three powders was compared by similarity evaluation method. And the indexes of parameter, parametric profile, and good compression were constructed to analyze the compressibility of the powder.Results The powders obtained by the three kinds of drying methods have poor fluidity and stability. The vacuum drying and vacuum microwave drying powders have good stackability, and the spray-dried powders have excellent homogeneity and compressibility. From the similarity, it can be seen that the similarity of powdery property of spray drying and vacuum drying extract is 79%, and 81.3% with vacuum microwave drying.Conclusion The physical fingerprint of TCM can be used to evaluate the influence of different drying methods on the powder science properties of Chinese medicine extract powder and the influence of physical properties on the formability of the preparation, which provides a new evaluation method for the Chinese medicine extract powder.

国家自然科学基金资助项目（81673613）；江西省科技条件平台建设项目（20142BCD40037）