中药材是中医药防病治病最重要的物质手段，其内在质量关乎中医药的临床疗效和安全用药。针对中药材质量优劣性评价的难点，以黄芪、款冬花、柴胡等山西道地药材为研究对象，探索了代谢组学技术在中药材质量优劣性评价中的应用。对近10年来代谢组学应用于中药材质量评价的研究进展进行总结，并对其应用前景和下一步的研究重点进行展望，以期为中药材质量精准评价及质量标准的进一步提升奠定基础。

Traditional Chinese medicinal materials (TCMM) are the material basis for traditional Chinese medicine (TCM), and the quality of the herbals was closely related with the efficacy and safety of TCM in clinic. Aiming at the difficulty in the quality evaluation of TCMM, some genuine herbals in Shanxi province, such as Astragali Radix, Farfarae Flos, and Buplerui Radix, were used as example, to investigate the application potential of the metabolomic approach. In order to lay the foundation for the accurate quality evaluation and further improvement of quality standard of TCMM, the studies in the recent ten years were summarized, and the prospect as well as the future research focus was also discussed.

国家自然科学基金资助项目（31770362，31570346，31270008，30900118，31100244）；山西省科技创新重点团队（201705D131028-17）